PDHA1, Monoclonal Antibody

mitochondrial; PDHA1; pdha1a; pdha1b; PHE1A; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase E1 alpha 1; Pyruvate dehydrogenase E1 component subunit alpha; somatic form

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG

Mouse

Store at -20 degree C. Stable for one year from the date of shipment.

Small volumes of anti-PDHA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO, and provides the primary link between glycolysis and the tricarboxylic acid cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase, dihydrolipoamide acetyltransferase and lipoamide dehydrogenase. The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Membrane; Lung Cancer

Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

WB: 1:1000-1:5000
IP: 10 tests
FC/FACS: 1:100-1:200

Predicted MW: 43kDa

pyruvate dehydrogenase E1 alpha 1 subunit

pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

PHE1A  [Similar Products]

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.

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