BAFF, Polyclonal Antibody

Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor(ligand) superfamily, member 13b; ApoL related ligand TALL 1 antibody; B cell Activating Factor antibody; B cell Activating Factor antibody; B lymphocyte stimulator antibody; B-cell-activating factor antibody; BAFF antibody; BLYS antibody; CD 257 antibody; CD257 antibody; CD257 antigen antibody; delta BAFF antibody; Dendritic cell derived TNF like molecule antibody; Dendritic cell-derived TNF-like molecule antibody; DTL antibody; DTL precursor antibody; PRO738 antibody; soluble form antibody; TALL 1 antibody; TALL-1 antibody; TALL1 antibody; THANK antibody; TN13B_HUMAN antibody; TNF and APOL related leukocyte expressed ligand 1 antibody; TNF homolog that activates apoptosis antibody; TNF homolog that activates apoptosis NKFB and JNK. antibody; TNF- and APOL-related leukocyte expressed ligand 1 antibody; TNFSF13B antibody; TNFSF20 antibody; Tumor necrosis factor ligand superfamily member 13B antibody; Tumor necrosis factor ligand superfamily member 20 antibody; Tumor necrosis factor like protein ZTNF4 antibody; Tumor necrosis factor superfamily member 13B antibody; UNQ401 antibody; ZTNF4 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-TNFSF13B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 13B(TNFSF13B) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system(CNS) lymphomas. The TNF superfamily member B cell-activating factor(BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA.Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology. The B cell activating factor BAFF(BlyS/TALL-1/zTNF4) is a tumor necrosis factor(TNF)-related ligand that promotes B cell survival and binds to three receptors(BCMA, TACI, and the recently described BAFF-R). Human BAFF was mapped to chromosome 13q32-34.4. The standard used in this kit is recombinant soluble human BAFF(A134-L295) with the molecular mass of 19.6KDa.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Anti-BAFF antibody, MBS175287, Western blotting
Lane 1: Recombinant Human BAFF Protein 10ng
Lane 2: Recombinant Human BAFF Protein 5ng
Lane 3: Recombinant Human BAFF Protein 2.5ng

Anti-BAFF antibody, MBS175287, IHC(P)
IHC(P): Human Tonsil Tissue

17,578 Da

tumor necrosis factor (ligand) superfamily, member 13b

tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20

Tumor necrosis factor ligand superfamily member 13B

BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1  [Similar Products]

TN13B_HUMAN

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Apoptosis; Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; positive regulation of cell proliferation; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; immune response; signal transduction

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