kinesin family member 21A, ELISA Kit

Human Kinesin-like protein KIF21A (KIF21A) ELISA kit; CFEOM; CFEOM1; DKFZp779C159; FEOM; FEOM1; FLJ20052; KIAA1708; Fibrosis of extraocular muscles; congenital; 1; autosomal dominant; KIF21A variant protein; NY-REN-62 antigen; fibrosis of the extraocular; kinesin family member 21A

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of KIF21A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9334182 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the kinesin family member 21A (KIF21A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KIF21A. The ELISA analytical biochemical technique of the MBS9334182 kit is based on KIF21A antibody-KIF21A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KIF21A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KIF21A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

187,179 Da

kinesin family member 21A

kinesin-like protein KIF21A; renal carcinoma antigen NY-REN-62

Kinesin-like protein KIF21A

KIAA1708; KIF2  [Similar Products]

KI21A_HUMAN

This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

KIF21A: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: kinesin complex; microtubule; cytoplasm

Molecular Function: protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: metabolic process; microtubule-based movement

Disease: Fibrosis Of Extraocular Muscles, Congenital, 1

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