Full Product Name
BMP-7 Antibody
Product Gene Name
anti-BMP-7 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P18075
Form/Format
Purified by peptide affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-BMP-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BMP-7 antibody
Rabbit polyclonal BMP-7(1) antibody was raised against a peptide from near the C terminal residues of human BMP-7 protein.
Product Categories/Family for anti-BMP-7 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-BMP-7 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BMP-7 antibody
Peptide ELISA: 1:1,000-1:10000
WB: 1:200-1:1,000
IHC: 1:50-200.
Testing Data of anti-BMP-7 antibody
Testing Data of anti-BMP-7 antibody
NCBI/Uniprot data below describe general gene information for BMP-7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001710.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001719.2
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UniProt Primary Accession #
P18075
[Other Products]
UniProt Secondary Accession #
Q9H512; Q9NTQ7[Other Products]
UniProt Related Accession #
P18075[Other Products]
Molecular Weight
49,313 Da
NCBI Official Full Name
bone morphogenetic protein 7 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 7
NCBI Official Symbol
BMP7 [Similar Products]
NCBI Official Synonym Symbols
OP-1
[Similar Products]
NCBI Protein Information
bone morphogenetic protein 7
UniProt Protein Name
Bone morphogenetic protein 7
UniProt Synonym Protein Names
Osteogenic protein 1; OP-1; INN: Eptotermin alfa
UniProt Gene Name
BMP7 [Similar Products]
UniProt Synonym Gene Names
OP1; BMP-7; OP-1 [Similar Products]
NCBI Summary for BMP-7
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
UniProt Comments for BMP-7
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Product References and Citations for anti-BMP-7 antibody
(1)Sengle, G., Ono, R.N., Lyons, K.M., et al. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol. 381 (4), 1025-1039 (2008).
Research Articles on BMP-7
1. On the contrary, BMP7 specific antibody inhibits the HNK-induced activation of p53 in colon cancer cells and partly decreases the total level of p53. Our findings suggested that HNK may be a promising anticancer drug for CRC; activation of p53 plays an important role in the anticancer activity of HNK, which may be initialized partly by the HNK-induced upregulation of BMP7.
Precautions
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Disclaimer
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