FOXF1, Polyclonal Antibody

Forkhead box protein F1; Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1; FOXF1; FKHL5; FREAC1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This FOXF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human FOXF1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-FOXF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene belongs to the forkhead family of transcription
factors which is characterized by a distinct forkhead domain. The
specific function of this gene has not yet been determined;
however, it may play a role in the regulation of pulmonary genes as
well as embryonic development.

Western Blot (WB), ELISA (EIA)

WB~~1:1000

FOXF1 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the FOXF1 antibody detected the FOXF1 protein (arrow).

40122

forkhead box F1

forkhead box protein F1

Forkhead box protein F1

FKHL5; FREAC1; FREAC-1  [Similar Products]

FOXF1_HUMAN

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

FOXF1: Probable transcription activator for a number of lung- specific genes. Defects in FOXF1 are the cause of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). ACDMPV is a rare malformation due to abnormal development of the capillary vascular system in the lungs. Histologically, it is characterized by failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.

Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; DNA binding; sequence-specific DNA binding

Biological Process: transcription from RNA polymerase II promoter; extracellular matrix organization and biogenesis; negative regulation of mast cell degranulation; heart development; positive regulation of transcription, DNA-dependent; establishment of epithelial cell polarity; negative regulation of transcription from RNA polymerase II promoter; lateral mesodermal cell differentiation; cell-cell adhesion; embryonic digestive tract morphogenesis; embryonic foregut morphogenesis; pancreas development; positive regulation of mesenchymal cell proliferation; regulation of smooth muscle cell differentiation; detection of wounding; vasculogenesis; blood vessel development; smoothened signaling pathway; somitogenesis; in utero embryonic development; respiratory tube development; morphogenesis of a branching structure; gut development; negative regulation of inflammatory response; midgut development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; embryonic ectodermal gut morphogenesis; determination of left/right symmetry; alveolus development; lung development; positive regulation of cell migration

Disease: Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Saito, R.A., et al. Cancer Res. 70(7):2644-2654(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Nilsson, J., et al. Cancer Res. 70(5):2020-2029(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Shaw-Smith, C. Eur J Med Genet 53(1):6-13(2010)

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