FOXF1, Peptide

FOXF1 (Forkhead Box F1, Drosophila Forkhead Homolog Like 5, FKHL5, Forkhead-Related Activator 1, FREAC1) Control Peptide (KLH)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 16; NC_000016.9 (86544133..86548070). Location: 16q24

Recognizes FOXF1. Species Crossreactivity: Human and rodent.

Highly Purified
Highly purified (HPLC, MS)

Supplied as a liquid in PBS. No preservative added. Conjugated with KLH.

Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
 

Small volumes of FOXF1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Molecular Biology; MB-Transcription Factors

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Suitable for use in ELISA, Western Blotting, Immunoprecipitation, Immunohistochemistry and or Immunocytochemistry.

40,122 Da[Similar Products]

forkhead box F1

forkhead box protein F1; FREAC-1; forkhead-related activator 1; forkhead-related protein FKHL5; Forkhead, drosophila, homolog-like 5; forkhead-related transcription factor 1

Forkhead box protein F1

FKHL5; FREAC1; FREAC-1  [Similar Products]

FOXF1_HUMAN

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]

Function: Probable transcription activator for a number of lung-specific genes. Ref.1

Subcellular location: Nucleus

Probable.

Tissue specificity: Expressed in lung and placenta. Ref.6

Developmental stage: Expressed in fetal lung. Ref.6

Domain: Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation.

Involvement in disease: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) [MIM:265380]: A rare developmental disorder characterized by abnormal development of the capillary vascular system in the lungs. Histological features include failure of formation and ingrowth of alveolar capillaries, medial muscular thickening of small pulmonary arterioles with muscularization of the intraacinar arterioles, thickened alveolar walls, and anomalously situated pulmonary veins running alongside pulmonary arterioles and sharing the same adventitial sheath. Less common features include a reduced number of alveoli and a patchy distribution of the histopathologic changes. Affected infants present with respiratory distress and the disease is fatal within the newborn period. Additional features include multiple congenital anomalies affecting the cardiovascular, gastrointestinal, genitourinary, and musculoskeletal systems, as well as disruption of the normal right-left asymmetry of intrathoracic or intraabdominal organs. ACDMPV is a rare cause of persistent pulmonary hypertension of the newborn, an abnormal physiologic state caused by failure of transition of the pulmonary circulation from the high pulmonary vascular resistance of the fetus to the low pulmonary vascular resistance of the newborn.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7

Sequence similarities: Contains 1 fork-head DNA-binding domain.

Caution: It is uncertain whether Met-1 or Met-26 is the initiator.

Sequence caution: The sequence AAC50399.1 differs from that shown. Reason: Erroneous initiation. The sequence AAC61576.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH89442.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG36851.1 differs from that shown. Reason: Frameshift at several positions.

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