Full Product Name
SCN3A (Sodium Channel Protein Type 3 Subunit alpha, Sodium Channel Protein Brain III Subunit alpha, Sodium Channel Protein Type III Subunit alpha, Voltage-gated Sodium Channel Subtype III, Voltage-gated Sodium Channel Subunit alpha Nav1.3, KIAA1356, NAC3)
Product Synonym Names
Anti -SCN3A (Sodium Channel Protein Type 3 Subunit alpha, Sodium Channel Protein Brain III Subunit alpha, Sodium Channel Protein Type III Subunit alpha, Voltage-gated Sodium Channel Subtype III, Voltage-gated Sodium Channel Subunit alpha Nav1.3, KIAA1356, NAC3)
Product Gene Name
anti-SCN3A antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
LCESGEMDAL RIQMEDRFMA SNPSKVSYEP ITTTLKRKQE EVSAAIIQRN FRCYLLKQRL KNISSNYNKE AIKGRIDLPI KQDMIIDKLN GNSTPEKTDG *
Chromosome Location
Chromosome: 2; NC_000002.11 (165944030..166060577, complement). Location: 2q24
3D Structure
ModBase 3D Structure for Q9NY46
Specificity
Recognizes human SCN3A.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Partial recombinant corresponding to aa1861-1961 from human SCN3A (NP_008853) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-SCN3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SCN3A antibody
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Product Categories/Family for anti-SCN3A antibody
Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-SCN3A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SCN3A antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for SCN3A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001075146.1
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NCBI GenBank Nucleotide #
NM_001081677.1
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UniProt Primary Accession #
Q9NY46
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UniProt Secondary Accession #
Q16142; Q53SX0; Q9BZB3; Q9C006; Q9NYK2; Q9P2J1; Q9UPD1; Q9Y6P4[Other Products]
UniProt Related Accession #
Q9NY46[Other Products]
Molecular Weight
226,294 Da[Similar Products]
NCBI Official Full Name
sodium channel protein type 3 subunit alpha isoform 3
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type III, alpha subunit
NCBI Official Symbol
SCN3A [Similar Products]
NCBI Official Synonym Symbols
NAC3; Nav1.3
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NCBI Protein Information
sodium channel protein type 3 subunit alpha; brain III voltage-gated sodium channel; voltage-gated sodium channel subtype III; sodium channel protein type III subunit alpha; sodium channel protein brain III subunit alpha; voltage-gated sodium channel subunit alpha Nav1.3; sodium channel, voltage-gated, type III, alpha polypeptide
UniProt Protein Name
Sodium channel protein type 3 subunit alpha
UniProt Synonym Protein Names
Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3
Protein Family
Sodium channel protein
UniProt Gene Name
SCN3A [Similar Products]
UniProt Synonym Gene Names
KIAA1356; NAC3 [Similar Products]
UniProt Entry Name
SCN3A_HUMAN
NCBI Summary for SCN3A
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SCN3A
SCN3A: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q24
Cellular Component: voltage-gated sodium channel complex; cytoplasm; plasma membrane
Molecular Function: voltage-gated sodium channel activity
Biological Process: sodium ion transport; generation of action potential
Research Articles on SCN3A
1. This study demonistrated that associated with a duplication of the SCN2A and SCN3A gene cluster on 2q24 in patient with early onset epilepsy.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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