Product Name
Dual oxidase maturation factor 2 (DUOXA2), Recombinant Protein
Full Product Name
Recombinant Human Dual oxidase maturation factor 2 (DUOXA2)
Product Gene Name
DUOXA2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-320aa; full length protein
Sequence
MTLWNGVLPF YPQPRHAAGF SVPLLIVILV FLALAASFLL ILPGIRGHSR WFWLVRVLLS LFIGAEIVAV HFSAEWFVGT VNTNTSYKAF SAARVTARVR LLVGLEGINI TLTGTPVHQL NETIDYNEQF TWRLKENYAA EYANALEKGL PDPVLYLAEK FTPSSPCGLY HQYHLAGHYA SATLWVAFCF WLLSNVLLST PAPLYGGLAL LTTGAFALFG VFALASISSV PLCPLRLGSS ALTTQYGAAF WVTLATGVLC LFLGGAVVSL QYVRPSALRT LLDQSAKDCS QERGGSPLIL GDPLHKQAAL PDLKCITTNL
3D Structure
ModBase 3D Structure for Q1HG44
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DUOXA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for DUOXA2 recombinant protein
Transmembrane Protein
Application Notes for DUOXA2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for DUOXA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_997464.2
[Other Products]
NCBI GenBank Nucleotide #
NM_207581.3
[Other Products]
UniProt Primary Accession #
Q1HG44
[Other Products]
UniProt Secondary Accession #
B2RPI9; H0YNQ6[Other Products]
UniProt Related Accession #
Q1HG44[Other Products]
Molecular Weight
12,964 Da
NCBI Official Full Name
dual oxidase maturation factor 2
NCBI Official Synonym Full Names
dual oxidase maturation factor 2
NCBI Official Symbol
DUOXA2 [Similar Products]
NCBI Official Synonym Symbols
TDH5; SIMNIPHOM
[Similar Products]
NCBI Protein Information
dual oxidase maturation factor 2
UniProt Protein Name
Dual oxidase maturation factor 2
UniProt Synonym Protein Names
Dual oxidase activator 2
Protein Family
Dual oxidase maturation factor
UniProt Gene Name
DUOXA2 [Similar Products]
UniProt Entry Name
DOXA2_HUMAN
NCBI Summary for DUOXA2
This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.[provided by RefSeq, Feb 2010]
UniProt Comments for DUOXA2
DUOXA2: Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Defects in DUOXA2 are the cause of thyroid dyshormonogenesis 5 (TDH5). A disorder due to thyroid dyshormonogenesis, causing hypothyroidism, goiter, and variable mental deficits derived from unrecognized and untreated hypothyroidism. Belongs to the DUOXA family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane
Biological Process: hydrogen peroxide metabolic process; protein transport; regulation of inflammatory response
Disease: Thyroid Dyshormonogenesis 5
Research Articles on DUOXA2
1. a novel DUOXA2 mutation (I26M) causing congenital hypothyroidism with goiter, which affected H2O2 generation but did not alter the protein expression levels, further confirming the essential role of DUOXA2 in thyroid hormone synthesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
