Full Product Name
SGK269 Antibody
Product Synonym Names
Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269; PEAK1; KIAA2002
Product Gene Name
anti-SGK269 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H792
Specificity
SGK269 antibody detects endogenous levels of total SGK269 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human SGK269.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-SGK269 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SGK269 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-SGK269 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SGK269 antibody
WB: 1:500~1:1000
ELISA: 1:5000
Western Blot of anti-SGK269 antibody
Western blot analysis of extracts from 3T3 cells, using SGK269 antibody.
NCBI/Uniprot data below describe general gene information for SGK269. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079052.2
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NCBI GenBank Nucleotide #
NM_024776.3
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UniProt Primary Accession #
Q9H792
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UniProt Secondary Accession #
Q6ZS78; Q8NAZ4; Q8NCM3; Q8TEG7[Other Products]
UniProt Related Accession #
Q9H792[Other Products]
Molecular Weight
193,106 Da
NCBI Official Full Name
pseudopodium-enriched atypical kinase 1
NCBI Official Synonym Full Names
pseudopodium enriched atypical kinase 1
NCBI Official Symbol
PEAK1 [Similar Products]
NCBI Official Synonym Symbols
SGK269
[Similar Products]
NCBI Protein Information
pseudopodium-enriched atypical kinase 1
UniProt Protein Name
Pseudopodium-enriched atypical kinase 1
UniProt Synonym Protein Names
Sugen kinase 269; Tyrosine-protein kinase SgK269
UniProt Gene Name
PEAK1 [Similar Products]
UniProt Synonym Gene Names
KIAA2002 [Similar Products]
NCBI Summary for SGK269
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
UniProt Comments for SGK269
Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN.
Product References and Citations for anti-SGK269 antibody
Zody M.C., Nature 440:671-675(2006). Jikuya H., Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. Ohara O., DNA Res. 9:47-57(2002).
Research Articles on SGK269
1. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.
Precautions
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Disclaimer
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