Product Name
Annexin A11 (ANXA11), Recombinant Protein
Full Product Name
Recombinant Human Annexin A11
Product Synonym Names
ANXA11 Human; Annexin A11 Human Recombinant; Annexin A11; 56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50; ANXA11; ANX11; CAP50
Product Gene Name
ANXA11 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG NPPSRMPSY PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA SRSNEHIREL NRAYKAEFKK TLEEAIRSDT GHFQRLLIS LSQGNRDEST NVDMSLAQRD AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS LYHDISGDTS GDYRKILLKI CGGND
3D Structure
ModBase 3D Structure for P50995
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The ANXA11 solution (0.25 mg/ml) contains 20% glycerol, 2mM DTT and 100mM NaCl.
Sterile Filtered colorless solution.
Preparation and Storage
ANXA11 should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Other Notes
Small volumes of ANXA11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ANXA11 recombinant protein
Description: ANXA11 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 525 amino acids (1-505 a.a.) and having a molecular mass of 56.6kDa. The ANXA11 is purified by proprietary chromatographic techniques.
Introduction: Annexin A11 (ANXA11) belongs to the annexin family, which is a group of calcium-dependent phospholipid-binding proteins. Annexins have distinctive N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-s. Annexin A11 binds specifically to calcyclin in a calcium-dependent manner. Moreover, ANXA11 is required for midbody formation and completion of the terminal phase of cytokinesis. The ANXA11 protein is a 56kDa antigen recognized by sera from patients with various autoimmune diseases.
Product Categories/Family for ANXA11 recombinant protein
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Annexin
NCBI/Uniprot data below describe general gene information for ANXA11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001148.1
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NCBI GenBank Nucleotide #
NM_001157.2
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UniProt Primary Accession #
P50995
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UniProt Secondary Accession #
B4DVE7[Other Products]
UniProt Related Accession #
P50995[Other Products]
Molecular Weight
51,242 Da
NCBI Official Full Name
annexin A11 isoform 1
NCBI Official Synonym Full Names
annexin A11
NCBI Official Symbol
ANXA11 [Similar Products]
NCBI Official Synonym Symbols
ANX11; CAP50
[Similar Products]
NCBI Protein Information
annexin A11; 56 kDa autoantigen; CAP-50; annexin XI; annexin-11; autoantigen, 56-kD; calcyclin-associated annexin 50
UniProt Protein Name
Annexin A11
UniProt Synonym Protein Names
56 kDa autoantigen; Annexin XI; Annexin-11; Calcyclin-associated annexin 50; CAP-50
UniProt Gene Name
ANXA11 [Similar Products]
UniProt Synonym Gene Names
ANX11; CAP-50 [Similar Products]
UniProt Entry Name
ANX11_HUMAN
NCBI Summary for ANXA11
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-s. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]
UniProt Comments for ANXA11
ANXA11: a calcium/phospholipid-binding protein found throughout the nucleoplasm at interphase and at the mitotic phase is concentrated at the loop-like structure around the mitotic apparatus. May interact with calcyclin (S100A6) in vivo. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Motility/polarity/chemotaxis; Lipid-binding; Calcium-binding; Nuclear envelope
Chromosomal Location of Human Ortholog: 10q23
Cellular Component: nucleoplasm; specific granule; azurophil granule; membrane; cytoplasm; melanosome; spindle; nuclear envelope; phagocytic vesicle; midbody
Molecular Function: protein binding; calcium-dependent phospholipid binding; phosphatidylethanolamine binding; calcium ion binding; calcium-dependent protein binding
Biological Process: response to calcium ion; phagocytosis
Research Articles on ANXA11
1. the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized--{REVIEW}
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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