Product Name
Lamin B1 (LMNB), Polyclonal Antibody
Popular Item
Full Product Name
Anti-Lamin B1 Rabbit pAb
Product Synonym Names
LMN; ADLD; LMN2; Lamin B1
Product Gene Name
anti-LMNB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20700
Species Reactivity
Human, Mouse, Rat
Specificity
Lamin B1 Antibody detects endogenous levels of total Lamin B1
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Lamin B1
Subcellular Location
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-LMNB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LMNB antibody
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.
Applications Tested/Suitable for anti-LMNB antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes for anti-LMNB antibody
WB: 1:3000-1:10000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50
Western Blot (WB) of anti-LMNB antibody
Western blot analysis of Lamin B1 expression in (1) Hela cell lysate; (2) Jurkat cell lysate; (3) Mouse brain lysate; (4) Rat heart lysate with Lamin B1 Antibody.
Immunohistochemistry (IHC) of anti-LMNB antibody
Immunohistochemical analysis of paraffin-embedded rat liver, using Lamin B1 Antibody.
Immunofluorescence (IF) of anti-LMNB antibody
Immunofluorescent analysis of HepG2 cells, using Lamin B1 Antibody.
NCBI/Uniprot data below describe general gene information for LMNB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005564.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005573.3
[Other Products]
UniProt Primary Accession #
P20700
[Other Products]
UniProt Secondary Accession #
Q3SYN7; Q96EI6; B2R6J6[Other Products]
UniProt Related Accession #
P20700[Other Products]
NCBI Official Full Name
lamin-B1 isoform 1
NCBI Official Synonym Full Names
lamin B1
NCBI Official Symbol
LMNB1 [Similar Products]
NCBI Official Synonym Symbols
LMN; ADLD; LMN2; LMNB
[Similar Products]
NCBI Protein Information
lamin-B1
UniProt Protein Name
Lamin-B1
UniProt Gene Name
LMNB1 [Similar Products]
UniProt Synonym Gene Names
LMN2; LMNB [Similar Products]
NCBI Summary for LMNB
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant *****-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for LMNB
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Research Articles on LMNB
1. In this report we show that increased self-association propensity of mutant LA modulates the LA-LB1 interaction and precludes the formation of an otherwise uniform laminar network. Our results might highlight the role of homotypic and heterotypic interactions of LA in the pathogenesis of DCM and hence laminopathies in the broader sense.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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