Product Name
Lamin B1 (LMNB1), Polyclonal Antibody
Full Product Name
Lamin B1 Antibody
Product Synonym Names
LAM1; LMN2; LMNB; LMNB1; Lamin-B1
Product Gene Name
anti-LMNB1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20700
Species Reactivity
Human, Mouse, Rat
Specificity
Lamin B1 antibody detects endogenous levels of Lamin B1.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human Lamin B1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LMNB1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-LMNB1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Western Blot (WB) of anti-LMNB1 antibody
Western blot analysis of lysate from COLO cells, using Lamin B1 antibody.
Immunohistochemistry (IHC) of anti-LMNB1 antibody
Immunohistochemistry analysis of Lamin B1 antibody in paraffin-embedded human brain tissue.
NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005564.1
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NCBI GenBank Nucleotide #
NM_005573.3
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UniProt Primary Accession #
P20700
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UniProt Secondary Accession #
Q3SYN7; Q96EI6; B2R6J6[Other Products]
UniProt Related Accession #
P20700[Other Products]
NCBI Official Full Name
lamin-B1 isoform 1
NCBI Official Synonym Full Names
lamin B1
NCBI Official Symbol
LMNB1 [Similar Products]
NCBI Official Synonym Symbols
LMN; ADLD; LMN2; LMNB
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NCBI Protein Information
lamin-B1
UniProt Protein Name
Lamin-B1
UniProt Gene Name
LMNB1 [Similar Products]
UniProt Synonym Gene Names
LMN2; LMNB [Similar Products]
NCBI Summary for LMNB1
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant *****-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for LMNB1
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Research Articles on LMNB1
1. These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
