Product Name
CYP11B1/2, Polyclonal Antibody
Full Product Name
CYP11B1/2 Polyclonal Antibody
Product Gene Name
anti-CYP11B1/2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15538
Other Notes
Small volumes of anti-CYP11B1/2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYP11B1/2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000488.3
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NCBI GenBank Nucleotide #
NM_000497.3
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UniProt Primary Accession #
P15538
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UniProt Secondary Accession #
Q14095; Q4VAQ8; Q4VAQ9; Q9UML2[Other Products]
UniProt Related Accession #
P15538[Other Products]
Molecular Weight
49,750 Da
NCBI Official Full Name
cytochrome P450 11B1, mitochondrial isoform 1
NCBI Official Synonym Full Names
cytochrome P450 family 11 subfamily B member 1
NCBI Official Symbol
CYP11B1 [Similar Products]
NCBI Official Synonym Symbols
FHI; CPN1; CYP11B; P450C11
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NCBI Protein Information
cytochrome P450 11B1, mitochondrial
UniProt Protein Name
Cytochrome P450 11B1, mitochondrial
UniProt Synonym Protein Names
CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)
UniProt Gene Name
CYP11B1 [Similar Products]
UniProt Synonym Gene Names
S11BH; Cytochrome P450C11 [Similar Products]
NCBI Summary for CYP11B1/2
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP11B1/2
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Research Articles on CYP11B1/2
1. we report clinical, genetic, hormonal, and structural effects of CYP11B1 gene mutations in the largest international cohort of 108 patients with steroid 11b-hydroxylase deficiency CAH.
Precautions
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Disclaimer
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