Full Product Name
Pax-6 Antibody
Product Gene Name
anti-Pax-6 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P26367
Other Notes
Small volumes of anti-Pax-6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-Pax-6 antibody
Western blot analysis Pax-6 using HepG2 whole cell lysates
NCBI/Uniprot data below describe general gene information for Pax-6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000271.1
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NCBI GenBank Nucleotide #
NM_000280.4
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UniProt Primary Accession #
P26367
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UniProt Secondary Accession #
Q6N006; Q99413[Other Products]
UniProt Related Accession #
P26367[Other Products]
NCBI Official Full Name
paired box protein Pax-6 isoform a
NCBI Official Synonym Full Names
paired box 6
NCBI Official Symbol
PAX6 [Similar Products]
NCBI Official Synonym Symbols
AN; AN2; FVH1; MGDA; WAGR; ASGD5; D11S812E
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NCBI Protein Information
paired box protein Pax-6
UniProt Protein Name
Paired box protein Pax-6
UniProt Synonym Protein Names
Aniridia type II protein; Oculorhombin
UniProt Gene Name
PAX6 [Similar Products]
UniProt Synonym Gene Names
AN2 [Similar Products]
NCBI Summary for Pax-6
This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
UniProt Comments for Pax-6
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (). Isoform 5a appears to function as a molecular switch that specifies target genes.
Research Articles on Pax-6
1. it was suggested that miR-19, upregulated in osteosarcoma cells, negatively regulated the expression of Pax6, which can promote the malignant phenotypes of osteosarcoma cells via activation of the extracellular signal-regulated kinase signaling pathways
Precautions
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Disclaimer
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