PAX6, Polyclonal Antibody

AN2; Paired box protein Pax-6; Aniridia type II protein; Oculorhombin

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of PAX6 protein.

Purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

Upon delivery aliquot and store at-20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-PAX6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to PAX6

Western Blot (WB)

WB: 1:500-1:1000

Western blot analysis of PAX6 expression in HEK293T (A) whole cell lysates.

48,218 Da

paired box 6

paired box protein Pax-6

Paired box protein Pax-6

AN2  [Similar Products]

This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (). Isoform 5a appears to function as a molecular switch that specifies target genes.

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