Product Name
Lamin B1 (Lmnb1), Peptide
Full Product Name
Lamin B1 Blocking Peptide
Product Gene Name
Lmnb1 peptide
[Similar Products]
Lamin B1 peptide (MBS843610) is used for blocking the activity of Lamin B1 antibody (MBS840711)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P14733
Form/Format
50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (lot specific)
Handling
The peptide solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of Lmnb1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for Lmnb1 peptide
Western Blot (WB)
Application Notes for Lmnb1 peptide
The peptide is used for blocking the antibody activity of Lamin B1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
NCBI/Uniprot data below describe general gene information for Lmnb1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034851.2
[Other Products]
NCBI GenBank Nucleotide #
NM_010721.2
[Other Products]
UniProt Primary Accession #
P14733
[Other Products]
UniProt Secondary Accession #
Q61791[Other Products]
UniProt Related Accession #
P14733[Other Products]
Molecular Weight
66,786 Da[Similar Products]
NCBI Official Full Name
lamin-B1
NCBI Official Synonym Full Names
lamin B1
NCBI Official Symbol
Lmnb1 [Similar Products]
NCBI Protein Information
lamin-B1
UniProt Protein Name
Lamin-B1
UniProt Gene Name
Lmnb1 [Similar Products]
UniProt Entry Name
LMNB1_MOUSE
UniProt Comments for Lmnb1
Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.
Protein type: Cytoskeletal
Cellular Component: nucleoplasm; nuclear membrane; nuclear matrix; membrane; lamin filament; intermediate filament; nuclear inner membrane; nuclear envelope; nucleus
Molecular Function: JUN kinase binding; phospholipase binding; structural molecule activity
Biological Process: G2/M-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of JNK cascade
Research Articles on Lmnb1
1. lamins B1 and B2 have unique roles in the developing brain and increased production of one B-type lamin does not fully complement loss of the other.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
