ankyrin 2, neuronal, ELISA Kit

Mouse Ankyrin-2 (ANK2) ELISA kit; DKFZp686M09125; DKFZp686P0948; FLJ38277; LQT4; ankyrin 2; ankyrin B; ankyrin; brain; ankyrin; nonerythroid; ankyrin-2; nonerythrocytic; brank-2; ankyrin 2; neuronal

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ANK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328614 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ankyrin 2, neuronal (ANK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ANK2. The ELISA analytical biochemical technique of the MBS9328614 kit is based on ANK2 antibody-ANK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ANK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ANK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

426,261 Da

ankyrin 2, brain

ankyrin-2; ankyrin-B; brain ankyrin

Ankyrin-2

ANK-2  [Similar Products]

ANK2_MOUSE

ANK2: In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. Defects in ANK2 are the cause of long QT syndrome type 4 (LQT4); also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. LQT4 displays many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves and atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes and prolonged QT interval on EKG is not a consistent feature. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Cellular Component: costamere; cell; integral to plasma membrane; T-tubule; M band; Z disc; postsynaptic membrane; cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; intracellular; cell junction; A band; sarcolemma

Molecular Function: protein binding, bridging; protein binding; potassium channel regulator activity; ATPase binding

Biological Process: regulation of apoptosis; cellular calcium ion homeostasis; protein localization; protein stabilization; regulation of heart rate; T-tubule organization and biogenesis; positive regulation of potassium ion transport; regulation of protein stability; regulation of calcium ion transport; signal transduction; positive regulation of calcium ion transport; cardiac muscle contraction

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