Product Name
MARVEL domain-containing protein 2 (MARVELD2), Recombinant Protein
Full Product Name
Recombinant Human MARVEL domain-containing protein 2 (MARVELD2)
Product Gene Name
MARVELD2 recombinant protein
[Similar Products]
Product Synonym Gene Name
TRIC[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-558aa; full length protein
Sequence
MSNDGRSRNR DRRYDEVPSD LPYQDTTIRT HPTLHDSERA VSADPLPPPP LPLQPPFGPD FYSSDTEEPA IAPDLKPVRR FVPDSWKNFF RGKKKDPEWD KPVSDIRYIS DGVECSPPAS PARPNHRSPL NSCKDPYGGS EGTFSSRKEA DAVFPRDPYG SLDRHTQTVR TYSEKVEEYN LRYSYMKSWA GLLRILGVVE LLLGAGVFAC VTAYIHKDSE WYNLFGYSQP YGMGGVGGLG SMYGGYYYTG PKTPFVLVVA GLAWITTIII LVLGMSMYYR TILLDSNWWP LTEFGINVAL FILYMAAAIV YVNDTNRGGL CYYPLFNTPV NAVFCRVEGG QIAAMIFLFV TMIVYLISAL VCLKLWRHEA ARRHREYMEQ QEINEPSLSS KRKMCEMATS GDRQRDSEVN FKELRTAKMK PELLSGHIPP GHIPKPIVMP DYVAKYPVIQ TDDERERYKA VFQDQFSEYK ELSAEVQAVL RKFDELDAVM SRLPHHSESR QEHERISRIH EEFKKKKNDP TFLEKKERCD YLKNKLSHIK QRIQEYDKVM NWDVQGYS
3D Structure
ModBase 3D Structure for Q8N4S9
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MARVELD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for MARVELD2 recombinant protein
Transmembrane Protein
Application Notes for MARVELD2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for MARVELD2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001033692.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001038603.2
[Other Products]
UniProt Primary Accession #
Q8N4S9
[Other Products]
UniProt Secondary Accession #
Q96NM9; A1BQX0; A1BQX1; A8KA97[Other Products]
UniProt Related Accession #
Q8N4S9[Other Products]
Molecular Weight
62,796 Da
NCBI Official Full Name
MARVEL domain-containing protein 2 isoform 1
NCBI Official Synonym Full Names
MARVEL domain containing 2
NCBI Official Symbol
MARVELD2 [Similar Products]
NCBI Official Synonym Symbols
Tric; DFNB49; MARVD2; MRVLDC2
[Similar Products]
NCBI Protein Information
MARVEL domain-containing protein 2
UniProt Protein Name
MARVEL domain-containing protein 2
UniProt Synonym Protein Names
Tricellulin
Protein Family
MARVEL domain-containing protein
UniProt Gene Name
MARVELD2 [Similar Products]
UniProt Synonym Gene Names
TRIC [Similar Products]
UniProt Entry Name
MALD2_HUMAN
NCBI Summary for MARVELD2
The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for MARVELD2
MARVELD2: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. Defects in MARVELD2 are the cause of deafness autosomal recessive type 49 (DFNB49). DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q13.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; integral to membrane; tight junction
Molecular Function: protein binding
Biological Process: intercellular junction assembly and maintenance; sensory perception of sound
Disease: Deafness, Autosomal Recessive 49
Research Articles on MARVELD2
1. The expressions of MARVELD2, CLDN1 and CLDN3 mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
