MARVELD2, Polyclonal Antibody

MARVELD2; DFNB49; MARVD2; MARVEL domain containing 2; Tric; Tricellulin; MRVLDC2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

MARVELD2 Antibody detects endogenous levels of total MARVELD2

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-MARVELD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis MARVELD2 using HepG2 whole cell lysates

62,796 Da

MARVEL domain containing 2

MARVEL domain-containing protein 2

MARVEL domain-containing protein 2

TRIC  [Similar Products]

MALD2_HUMAN

The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

MARVELD2: Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. Defects in MARVELD2 are the cause of deafness autosomal recessive type 49 (DFNB49). DFNB49 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; tight junction

Molecular Function: protein binding

Biological Process: intercellular junction assembly and maintenance; sensory perception of sound

Disease: Deafness, Autosomal Recessive 49

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