Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 (EIF2AK4), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of EIF2AK4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9909754 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 (EIF2AK4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EIF2AK4. The ELISA analytical biochemical technique of the MBS9909754 kit is based on EIF2AK4 antibody-EIF2AK4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EIF2AK4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EIF2AK4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

69,797 Da

eukaryotic translation initiation factor 2 alpha kinase 4

eIF-2-alpha kinase GCN2

eIF-2-alpha kinase GCN2

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: EC 2.7.11.1; GCN2 subfamily; Kinase, protein; Other group; PEK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: polysome

Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding

Biological Process: adaptive immune response; cell cycle arrest; cellular response to amino acid starvation; cellular response to cold; cellular response to leucine starvation; cellular response to UV; defense response to virus; DNA damage checkpoint; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; induction by virus of host autophagy; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translational initiation; negative regulation of translational initiation in response to stress; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; positive regulation of long-term synaptic potentiation; protein amino acid phosphorylation; protein autophosphorylation; regulation of translational initiation; regulation of translational initiation by eIF2 alpha phosphorylation; T cell activation involved in immune response; viral translation

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive

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