Product Name
PAPSS2, Polyclonal Antibody
Full Product Name
PAPSS2 Antibody, Biotin conjugated
Product Synonym Names
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; PAPS synthase 2; PAPSS 2; Sulfurylase kinase 2; SK 2; SK2; Sulfate adenylyltransferase; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; PAPSS2; ATPSK2
Product Gene Name
anti-PAPSS2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95340
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 protein (2-138AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PAPSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAPSS2 antibody
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity).
Product Categories/Family for anti-PAPSS2 antibody
Applications Tested/Suitable for anti-PAPSS2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for PAPSS2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001015880.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001015880.1
[Other Products]
UniProt Primary Accession #
O95340
[Other Products]
UniProt Secondary Accession #
Q9BZL2; Q9P0G6; Q9UHM1; Q9UKD3; Q9UP30[Other Products]
UniProt Related Accession #
O95340[Other Products]
Molecular Weight
69,970 Da
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform b
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 2
NCBI Official Symbol
PAPSS2 [Similar Products]
NCBI Official Synonym Symbols
SK2; BCYM4; ATPSK2
[Similar Products]
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
UniProt Synonym Protein Names
Sulfurylase kinase 2; SK 2; SK2
Protein Family
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase
UniProt Gene Name
PAPSS2 [Similar Products]
UniProt Synonym Gene Names
ATPSK2; PAPS synthase 2; PAPSS 2; SK 2; SK2; SAT [Similar Products]
NCBI Summary for PAPSS2
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PAPSS2
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth ().
Research Articles on PAPSS2
1. In an Amish population, using expression profiling of genes within regions identified by a meta-analysis GWAS of survival to age 90, we localized PAPSS2 as a candidate gene for extended life span. These results provide novel evidence for genetic loci implicated in longevity and incorporate gene expression results from a unique population to locate positional candidates.
Precautions
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