DMRT1, Monoclonal Antibody

Mouse Monoclonal [clone 1G11] (IgG1, k) to Human DMRT1; DMRT1; DMT1

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

2H1

Mouse

Human DMRT1

Immunoaffinity Purified

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Store at -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-DMRT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibitingmeiosis in undifferentiated spermatogonia and promoting mitosis, leadingto spermatogonial development and allowing abundant and continuousproduction of sperm.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 10 ug/ml
WB: 1:2000

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DMRT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DMRT1 (1:2000).

18,325 Da

doublesex and mab-3 related transcription factor 1

doublesex- and mab-3-related transcription factor 1

Doublesex- and mab-3-related transcription factor 1

DMT1  [Similar Products]

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis ().

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