Product Synonym Names
EPP; FCE
Product Gene Name
anti-FECH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22830
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human FECH
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-FECH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FECH antibody
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.
Applications Tested/Suitable for anti-FECH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FECH antibody
WB: 1:500-1:2000
IHC: 1:50-1:100
NCBI/Uniprot data below describe general gene information for FECH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000131.2
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NCBI GenBank Nucleotide #
NM_000140.3
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UniProt Primary Accession #
P22830
[Other Products]
UniProt Secondary Accession #
Q8IXN1; Q8NAN0; A8KA72[Other Products]
UniProt Related Accession #
P22830[Other Products]
NCBI Official Full Name
ferrochelatase, mitochondrial isoform b
NCBI Official Synonym Full Names
ferrochelatase
NCBI Official Symbol
FECH [Similar Products]
NCBI Official Synonym Symbols
EPP; FCE
[Similar Products]
NCBI Protein Information
ferrochelatase, mitochondrial
UniProt Protein Name
Ferrochelatase, mitochondrial
UniProt Synonym Protein Names
Heme synthase; Protoheme ferro-lyase
UniProt Gene Name
FECH [Similar Products]
NCBI Summary for FECH
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
UniProt Comments for FECH
Catalyzes the ferrous insertion into protoporphyrin IX.
Research Articles on FECH
1. Using a forward chemical genetic approach, the authors identified the heme synthesis enzyme ferrochelatase (FECH) as necessary for angiogenesis in vitro and in vivo FECH is overexpressed in wet age-related macular degeneration eyes and murine choroidal neovascularization.
Precautions
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Disclaimer
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