EIF2AK4, Polyclonal Antibody

GCN2-like protein; EIF2AK4; GCN2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-EIF2AK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Recommended dilution: WB:1:200-1:1000
IHC:1:20-1:200

Western blot
All lanes: EIF2AK4 antibody at 2ug/ml+mouse lung tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 187,184,70 kDa
Observed band size: 187 kDa

Immunohistochemistry of paraffin-embedded human prostatic cancer using MBS968761 at dilution 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS968761 at dilution 1:100

69,797 Da

Eukaryotic translation initiation factor 2-alpha kinase 4

GCN2; KIAA1338  [Similar Products]

E2AK4_HUMAN

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Translation; Other group; PEK family; GCN2 subfamily

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: polysome

Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; protein serine/threonine kinase activity; tRNA binding

Biological Process: cellular response to amino acid starvation; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive

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