Product Name
DMRT1, cDNA Clone
Full Product Name
DMRT1 cDNA Clone
Product Gene Name
DMRT1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcccaacg acgaggcatt cagcaagccc tctacaccgt cggaagcccc tcacgccccc ggggtaccgc cgcagggcag agccgggggc tttggcaaag cgtctggggc gctagtgggg gcggccagcg gctcgagcgc cgggggcagc agcagaggag gcggctccgg ctccggggcg tcggacctgg gtgccgggag caagaagtcc ccgcggctgc ccaagtgcgc acgctgcagg aaccacggct acgcctcgcc gctcaagggc cacaagcgct tctgcatgtg gcgcgactgc cagtgcaaga agtgcaacct gatcgccgag aggcagcgcg tgatggccgc gcaggtggcc ctgagaaggc agcaggccca ggaggaggaa ttgggtatca gccaccccat cccactgccc agtgcggccg agctgcttgt caaaagagag aacaatggca gtaacccgtg cctcatgact gagtgcagtg gcacctctca gccaccgccg gccagtgtcc ccaccactgc agcttcagag ggacgtatgg tcatccagga tattcctgct gtcaccagca gagggcatgt ggagaacaca cctgacctgg tttcagactc cacctactac agcagcttct accagccgtc tctgtttcct tattacaaca atctatacaa ctgcccgcag tactccatgg ccttggctgc tgattctgct tctggggagg tgggaaatcc cctcggggga tcccctgtga agaacagcct tcggggcctc cccggacctt atgtgcctgg tcagacagga aaccagtggc agatgaagaa catggagaac cgccatgcaa tgagctccca gtacaggatg cattcttact acccgcctcc ctcttacctg ggccagagcg tgccccagtt cttcactttt gaggatgctc cctcttaccc ggaagccagg gcgagcgtat tctcgccgcc cagcagtcaa gattctggct tggtttccct ctcgagcagc tctcctatta gtaacaagag cacaaaggca gtgcttgaat gtgagcctgc gtcggagccc agcagcttca cagtcactcc cgtcatcgag gaggacgagt ga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DMRT1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DMRT1. It may not necessarily be applicable to this product.
NCBI Accession #
BC040847
[Other Products]
UniProt Secondary Accession #
Q6T1H8; Q6T1H9; Q8IW77; B2R913[Other Products]
UniProt Related Accession #
Q9Y5R6[Other Products]
Molecular Weight
18,325 Da
NCBI Official Full Name
Homo sapiens doublesex and mab-3 related transcription factor 1, mRNA
NCBI Official Synonym Full Names
doublesex and mab-3 related transcription factor 1
NCBI Official Symbol
DMRT1 [Similar Products]
NCBI Official Synonym Symbols
DMT1; CT154
[Similar Products]
NCBI Protein Information
doublesex- and mab-3-related transcription factor 1
UniProt Protein Name
Doublesex- and mab-3-related transcription factor 1
UniProt Synonym Protein Names
DM domain expressed in testis protein 1
Protein Family
Doublesex and mab-3 related transcription factor
UniProt Gene Name
DMRT1 [Similar Products]
UniProt Synonym Gene Names
DMT1 [Similar Products]
UniProt Entry Name
DMRT1_HUMAN
NCBI Summary for DMRT1
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]
UniProt Comments for DMRT1
DMRT1: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. Defects in DMRT1 may be a cause of testicular germ cell tumor (TGCT). A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms. Defects in DMRT1 may be a cause of 46,XY sex reversal type 4 (SRXY4). A condition characterized by male-to- female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion. Belongs to the DMRT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9p24.3
Cellular Component: nucleus
Molecular Function: protein homodimerization activity; transcription factor activity
Biological Process: male sex determination; male sex differentiation; negative regulation of meiosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; Sertoli cell differentiation; sex differentiation
Research Articles on DMRT1
1. The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare.
Precautions
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Disclaimer
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