Cystic Fibrosis Transmembrane Conductance Regulator, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000007.13 (117120017..117308719). Location: 7q31.2

Store all reagents at 2-8 degree C

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Small volumes of CFTR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS031927 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CFTR. The ELISA analytical biochemical technique of the MBS031927 kit is based on CFTR antibody-CFTR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CFTR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CFTR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

168,142 Da

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

cystic fibrosis transmembrane conductance regulator; cAMP-dependent chloride channel; channel conductance-controlling ATPase

Cystic fibrosis transmembrane conductance regulator

ABCC7; CFTR  [Similar Products]

CFTR_HUMAN

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]

CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice

Protein type: Channel, chloride; Membrane protein, multi-pass; Transporter; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: recycling endosome; protein complex; microvillus; cell surface; cytoplasmic vesicle membrane; early endosome membrane; basolateral plasma membrane; cytoplasm; early endosome; apical plasma membrane; plasma membrane

Molecular Function: bicarbonate transmembrane transporter activity; chloride channel activity; protein binding; chloride channel inhibitor activity; enzyme binding; chloride transmembrane transporter activity; channel-conductance-controlling ATPase activity; ATP-binding and phosphorylation-dependent chloride channel activity; ATP binding; PDZ domain binding

Biological Process: response to drug; intracellular pH elevation; response to peptide hormone stimulus; cholesterol transport; iodide transport; water transport; transepithelial chloride transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; vasodilation; cholesterol biosynthetic process; cellular response to hormone stimulus; transport; response to estrogen stimulus; bicarbonate transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development

Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary

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