Mastermind-Like 3, Monoclonal Antibody

Anti -Mastermind-Like 3 (MAML3, CAGH3, ERDA3, GDN, TNRC3)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: X; NC_000023.10 (149529836..149682448). Location: Xq28

Monoclonal

IgG1

8C215

Mouse

Recognizes human Mastermind-Like 3.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-MAMLD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Antibodies; Abs to Transcription Factors

Western Blot (WB)

Suitable for use in Western Blot.

83,231 Da[Similar Products]

mastermind-like domain containing 1

mastermind-like domain-containing protein 1

Mastermind-like domain-containing protein 1

CG1; CXorf6  [Similar Products]

MAMD1_HUMAN

This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

MAMLD1: Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks s for RBPJ. Defects in MAMLD1 are a cause of X-linked hypospadias type 2 (HYSP2). Hypospadias is a common malformation in which the urethra opens on the ventral side of the penis. It is considered a complex disorder with both genetic and environmental factors involved in the pathogenesis. Hypospadias can occur alone on an apparently multifactorial basis or as part of syndromes. Belongs to the mastermind family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleus

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; male gonad development

Disease: Hypospadias 2, X-linked

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