Product Name
CYP2C8, Polyclonal Antibody
Full Product Name
CYP2C8 Polyclonal Antibody
Product Synonym Names
CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
Product Gene Name
anti-CYP2C8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human CYP2C8.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-164136
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CYP2C8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CYP2C8 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CYP2C8 antibody
WB: 1:500-1:2000, ELISA: 1:5000-1:20000
Western Blot (WB) of anti-CYP2C8 antibody
Western Blot analysis of 293 cells using CYP2C8 Polyclonal Antibody at dilution of 1:1000.
NCBI/Uniprot data below describe general gene information for CYP2C8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001185784.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001198855.1
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UniProt Secondary Accession #
Q5VX93; Q8WWB1; Q9UCZ9; A8K9N8; B0AZN2; B7Z1F6[Other Products]
UniProt Related Accession #
P10632[Other Products]
Molecular Weight
Calculated MW: 56
Observed MW: 55
NCBI Official Full Name
cytochrome P450 2C8 isoform b
NCBI Official Synonym Full Names
cytochrome P450 family 2 subfamily C member 8
NCBI Official Symbol
CYP2C8 [Similar Products]
NCBI Official Synonym Symbols
CPC8; CYPIIC8; MP-12/MP-20
[Similar Products]
NCBI Protein Information
cytochrome P450 2C8
UniProt Protein Name
Cytochrome P450 2C8
UniProt Synonym Protein Names
CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
Protein Family
Cytochrome
UniProt Gene Name
CYP2C8 [Similar Products]
UniProt Entry Name
CP2C8_HUMAN
NCBI Summary for CYP2C8
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP2C8
CYP2C8: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - linoleic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: endoplasmic reticulum membrane
Molecular Function: arachidonic acid epoxygenase activity; heme binding; iron ion binding; monooxygenase activity; steroid hydroxylase activity
Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; xenobiotic metabolic process
Research Articles on CYP2C8
1. Single nucleotide polymorphisms of CYP2C8,CYP2E1 and CYP4B1 are associated with susceptibility to gout in ethnic Han males population.
Precautions
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