Full Product Name
PKP2 Antibody
Product Gene Name
anti-PKP2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99959
Species Reactivity
Human, Rat
Specificity
PKP2 Antibody detects endogenous levels of total PKP2 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human PKP2.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-PKP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PKP2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PKP2 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-PKP2 antibody
Western blot analysis of lysates from HeLa and HepG2 cells, using PKP2 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for PKP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001005242.2
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NCBI GenBank Nucleotide #
NM_001005242.2
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UniProt Primary Accession #
Q99959
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UniProt Secondary Accession #
Q4VC01; Q99960; A0AV37; B8QFA1; B8QGS6; B8QGS7; D3DUW9[Other Products]
UniProt Related Accession #
Q99959[Other Products]
NCBI Official Full Name
plakophilin-2 isoform 2a
NCBI Official Synonym Full Names
plakophilin 2
NCBI Official Symbol
PKP2 [Similar Products]
NCBI Official Synonym Symbols
ARVD9
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NCBI Protein Information
plakophilin-2
UniProt Protein Name
Plakophilin-2
Protein Family
Plakophilin
UniProt Gene Name
PKP2 [Similar Products]
NCBI Summary for PKP2
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
UniProt Comments for PKP2
May play a role in junctional plaques.
Research Articles on PKP2
1. Screening for CNVs in desmosome genes is useful to identify the genetic basis of disease in clinically suspected ARVC patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
