Product Name
CART1 (ALX1), Monoclonal Antibody
Full Product Name
CART1 (CART-1, Cartilage Homeoprotein 1, Cartilage Paired-class Homeoprotein 1, ALX Homeobox Protein 1, ALX1)
Product Synonym Names
Anti -CART1 (CART-1, Cartilage Homeoprotein 1, Cartilage Paired-class Homeoprotein 1, ALX Homeobox Protein 1, ALX1)
Product Gene Name
anti-ALX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 12; Location: 12q21.31
3D Structure
ModBase 3D Structure for Q15699
Specificity
Recognizes human CART1.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 1% BSA and 0.05% sodium azide.
Immunogen
Partial sequence of recombinant full-length protein to human CART1
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ALX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ALX1 antibody
Antibodies; Abs to Transcription Factors, Homeobox (HOX)
Applications Tested/Suitable for anti-ALX1 antibody
Western Blot (WB), Gel Shift Assay (GS/EMSA)
Application Notes for anti-ALX1 antibody
Suitable for use in Dot Blot and Western Blot.
NCBI/Uniprot data below describe general gene information for ALX1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q15699
[Other Products]
UniProt Secondary Accession #
Q546C8; Q96FH4[Other Products]
UniProt Related Accession #
Q15699[Other Products]
Molecular Weight
36,961 Da[Similar Products]
NCBI Official Full Name
cartilage paired-class homeoprotein 1
NCBI Official Synonym Full Names
ALX homeobox 1
NCBI Official Symbol
ALX1 [Similar Products]
NCBI Official Synonym Symbols
FND3; CART1; ALX1
[Similar Products]
NCBI Protein Information
ALX homeobox protein 1; CART-1; cartilage paired-class homeoprotein 1
UniProt Protein Name
ALX homeobox protein 1
UniProt Synonym Protein Names
Cartilage homeoprotein 1
Protein Family
ALX homeobox protein
UniProt Gene Name
ALX1 [Similar Products]
UniProt Synonym Gene Names
CART1 [Similar Products]
UniProt Entry Name
ALX1_HUMAN
NCBI Summary for ALX1
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq]
UniProt Comments for ALX1
Cart1: Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3). The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 12q21.31
Cellular Component: nucleoplasm; Golgi apparatus; transcription factor complex; nucleus
Molecular Function: protein binding; protein heterodimerization activity; transcription corepressor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; multicellular organismal development; positive regulation of transcription, DNA-dependent; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic skeletal morphogenesis; anterior/posterior pattern formation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; brain development; mesenchymal cell development; cartilage condensation; embryonic limb morphogenesis
Disease: Frontonasal Dysplasia 3
Research Articles on ALX1
1. Disruption of CART1 (ALX1) causes extreme microphthalmia and severe facial clefting.
Precautions
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Disclaimer
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