Full Product Name
AQP2 Polyclonal Antibody
Product Gene Name
anti-AQP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.5mg/mL (lot specific)
Immunogen
Synthetic peptide of human AQP2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-AQP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AQP2 antibody
The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes, but when it is needed vasopressin binds to the cell surface vasopressin receptor, activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane so the aquaporin 2 can be used by the cell.
Applications Tested/Suitable for anti-AQP2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AQP2 antibody
IHC: 1:50-1:200
Immunohistochemistry (IHC) of anti-AQP2 antibody
Immunohistochemistry of paraffin-embedded Human renal cancer tissue using AQP2 Polyclonal Antibody at dilution 1:50
NCBI/Uniprot data below describe general gene information for AQP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000477.1
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NCBI GenBank Nucleotide #
NM_000486.5
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UniProt Secondary Accession #
Q9UD68[Other Products]
UniProt Related Accession #
P41181[Other Products]
Molecular Weight
28,837 Da
NCBI Official Full Name
aquaporin-2
NCBI Official Synonym Full Names
aquaporin 2 (collecting duct)
NCBI Official Symbol
AQP2 [Similar Products]
NCBI Official Synonym Symbols
AQP-CD; WCH-CD
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NCBI Protein Information
aquaporin-2; ADH water channel; AQP-2; aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct; water-channel aquaporin 2
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Gene Name
AQP2 [Similar Products]
UniProt Synonym Gene Names
AQP-2; AQP-CD [Similar Products]
UniProt Entry Name
AQP2_HUMAN
NCBI Summary for AQP2
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
UniProt Comments for AQP2
AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Transporter, aquaporin family; Membrane protein, integral; Membrane protein, multi-pass; Channel, misc.; Transporter
Chromosomal Location of Human Ortholog: 12q12-q13
Cellular Component: recycling endosome; protein complex; rough endoplasmic reticulum; membrane; clathrin-coated vesicle; lysosome; basolateral plasma membrane; integral to plasma membrane; early endosome; apical plasma membrane; plasma membrane; trans-Golgi network
Molecular Function: water transporter activity; glycerol transmembrane transporter activity; water channel activity; actin binding; glycerol channel activity; PDZ domain binding
Biological Process: actin filament depolymerization; glycerol transport; response to glucagon stimulus; cellular water homeostasis; apoptosis; water transport; response to lithium ion; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; renal water transport; hyperosmotic response; renal water homeostasis; positive regulation of calcium ion transport; response to calcium ion; transmembrane transport; aging
Disease: Diabetes Insipidus, Nephrogenic, Autosomal
Research Articles on AQP2
1. AQP2 is subjected to S-glutathionylation, which is modulated by reactive oxygen species production.
Precautions
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Disclaimer
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