Full Product Name
PKP2 Antibody
Product Synonym Names
Plakophilin-2
Product Gene Name
anti-PKP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99959
Species Reactivity
Human, Rat
Specificity
PKP2 Antibody detects endogenous levels of total PKP2
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-PKP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PKP2 antibody
Western Blot (WB)
Application Notes for anti-PKP2 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-PKP2 antibody
Western blot analysis of extracts from HeLa cells and HepG2 cells, using PKP2 antibody.
NCBI/Uniprot data below describe general gene information for PKP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001005242.2
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NCBI GenBank Nucleotide #
NM_001005242.2
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UniProt Primary Accession #
Q99959
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UniProt Secondary Accession #
Q4VC01; Q99960; A0AV37; B8QFA1; B8QGS6; B8QGS7; D3DUW9[Other Products]
UniProt Related Accession #
Q99959[Other Products]
NCBI Official Full Name
plakophilin-2 isoform 2a
NCBI Official Synonym Full Names
plakophilin 2
NCBI Official Symbol
PKP2 [Similar Products]
NCBI Official Synonym Symbols
ARVD9
[Similar Products]
NCBI Protein Information
plakophilin-2
UniProt Protein Name
Plakophilin-2
Protein Family
Plakophilin
UniProt Gene Name
PKP2 [Similar Products]
NCBI Summary for PKP2
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
UniProt Comments for PKP2
May play a role in junctional plaques.
Research Articles on PKP2
1. The rare incidence of PKP2 mutation in sudden unexplained noctural death syndrome (SUNDS, 1%) supports the previous viewpoint that SUNDS is most likely an allelic disorder as Brugada syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
