Product Name
Calnexin (CANX), Monoclonal Antibody
Full Product Name
Calnexin
Product Synonym Names
Anti -Calnexin
Product Gene Name
anti-CANX antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (179125930..179158642). Location: 5q35
3D Structure
ModBase 3D Structure for P27824
Species Reactivity
Human, Mouse
Specificity
Recognizes human Calnexin. Species Crossreactivity: mouse
Purity/Purification
Ascites
Ascites.
Form/Format
Supplied as a liquid, 40% glycerol.
Immunogen
Recombinant human calnexin.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CANX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CANX antibody
Antibodies; Abs to Calnexin
Applications Tested/Suitable for anti-CANX antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-CANX antibody
Suitable for use in ELISA, Immunohistochemistry, Immunocytochemistry, Immunoblot and Immunoprecipitation.
Dilution: Immunohistochemistry (frozen sections): 1:250-1:1000
Immunocytochemistry: 1:50-1:125
Immunoblot: 1:100-1:1000
Immunoprecipitation: 1:100-1:500
NCBI/Uniprot data below describe general gene information for CANX. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P27824
[Other Products]
UniProt Secondary Accession #
B2R5V8; D3DWQ3[Other Products]
UniProt Related Accession #
P27824; Q6ZP56[Other Products]
Molecular Weight
67,568 Da[Similar Products]
NCBI Official Full Name
calnexin
NCBI Official Synonym Full Names
calnexin
NCBI Official Symbol
CANX [Similar Products]
NCBI Official Synonym Symbols
CNX; P90; IP90; FLJ26570
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NCBI Protein Information
calnexin; OTTHUMP00000161516; OTTHUMP00000223184; OTTHUMP00000223187; major histocompatibility complex class I antigen-binding protein p88
UniProt Protein Name
Calnexin
UniProt Synonym Protein Names
IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
UniProt Gene Name
CANX [Similar Products]
UniProt Entry Name
CALX_HUMAN
NCBI Summary for CANX
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
UniProt Comments for CANX
Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Calcium-binding; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; membrane; cell soma; axon; melanosome; ribosome
Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; carbohydrate binding
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging
Research Articles on CANX
1. HLA-I, TAP1, CNX, LMP7, Erp57, Tapasin and ERAP1 were down-regulated in 68%, 44%, 48%, 40%, 52%, 32% and 20% of esophageal squamous cell carcinoma lesions then, respectively.
Precautions
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Disclaimer
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