Product Name
Troponin I (TNNI3), Monoclonal Antibody
Popular Item
Full Product Name
Troponin I antibody (Cardiac)
Product Synonym Names
Monoclonal Troponin I (Cardiac); Anti-Troponin I (Cardiac)
Product Gene Name
anti-TNNI3 antibody
[Similar Products]
Matching Pairs
Capture Antibody: Troponin I Clone #M805141 (MBS530979)
Detection Antibody: Troponin I Clone #M805142 (MBS530749)
Comments: Sensitive to 0.1 ng/ml by ELISA.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8MKD5
Purity/Purification
Troponin I antibody (Cardiac) was purified by chromatography on protein A Sepharose.
Form/Format
Protein A purified IgG supplied in PBS, pH 7.5, 0.1 % NaN3.
Biological Significance
Human troponin I is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein ? one dephospho, two monophospho and one bisphospho ? can coexist in the cell.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Troponin I antibody (cardiac) was raised in mouse using amino acid residues 86-90 of cTnI as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNNI3 antibody
Mouse monoclonal Troponin I antibody (Cardiac)
Product Categories/Family for anti-TNNI3 antibody
Cardiac Markers
Applications Tested/Suitable for anti-TNNI3 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TNNI3 antibody
Matched pair antibody available for Troponin I antibody (Cardiac): MBS530749
NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001003041.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001003041.1
[Other Products]
UniProt Primary Accession #
Q8MKD5
[Other Products]
UniProt Related Accession #
Q8MKD5[Other Products]
Molecular Weight
23,912 Da[Similar Products]
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Symbol
TNNI3 [Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
UniProt Gene Name
TNNI3 [Similar Products]
UniProt Entry Name
TNNI3_CANFA
UniProt Comments for TNNI3
TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.
Protein type: Motility/polarity/chemotaxis; Motor; Actin-binding
Research Articles on TNNI3
1. The objective of this study was to evaluate the correlation between anatomical components, clinical signs and several biomarkers, used to determine systemic inflammation and myocardial damage in dogs with brachycephalic upper airway obstructive syndrome.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
