Full Product Name
ACBP Antibody
Product Synonym Names
ACBD1; ACBP; acyl-CoA-binding; diazepam-binding inhibitor; endozepine; EP; GABA receptor modulator; DBI
Product Gene Name
anti-ACBP antibody
[Similar Products]
Product Synonym Gene Name
DBI[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07108
Specificity
ACBP antibody detects endogenous levels of ACBP.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ACBP.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ACBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACBP antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ACBP antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Western Blot (WB) of anti-ACBP antibody
Western blot analysis of lysate fromHuvEc cells, using ACBP antibody.
Immunohistochemistry (IHC) of anti-ACBP antibody
Immunohistochemistry analysis of ACBP antibody in paraffin-embedded human liver carcinoma tissue.
NCBI/Uniprot data below describe general gene information for ACBP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001073331.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001079862.2
[Other Products]
UniProt Primary Accession #
P07108
[Other Products]
UniProt Secondary Accession #
P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8; B8ZWD2; B8ZWD6; B8ZWD7[Other Products]
UniProt Related Accession #
P07108[Other Products]
NCBI Official Full Name
acyl-CoA-binding protein isoform 3
NCBI Official Synonym Full Names
diazepam binding inhibitor, acyl-CoA binding protein
NCBI Official Symbol
DBI [Similar Products]
NCBI Official Synonym Symbols
EP; ACBP; ACBD1; CCK-RP
[Similar Products]
NCBI Protein Information
acyl-CoA-binding protein
UniProt Protein Name
Acyl-CoA-binding protein
UniProt Synonym Protein Names
Diazepam-binding inhibitor; DBI; Endozepine; EP
UniProt Gene Name
DBI [Similar Products]
UniProt Synonym Gene Names
ACBP; DBI; EP [Similar Products]
NCBI Summary for ACBP
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACBP
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Research Articles on ACBP
1. ACBP increases the activity of ceramide synthase 2 (CerS2) by more than 2-fold and CerS3 activity by 7-fold. ACBP binds very-long-chain acyl-CoA esters, which is required for its ability to stimulate CerS activity.
Precautions
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Disclaimer
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