Product Name
IQSEC2, Blocking Peptide
Full Product Name
IQSEC2 Peptide
Product Synonym Names
IQ motif and Sec7 domain 2; Brefeldin-resistant Arf-GEF 1 protein; BRAG1; MRX1; IQ motif and Sec7 domain 2
Product Gene Name
IQSEC2 blocking peptide
[Similar Products]
IQSEC2 peptide (MBS154053) is used for blocking the activity of IQSEC2 antibody (MBS153419)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5JU85
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
18 amino acid peptide near the carboxy terminus of human IQSEC2.
Preparation and Storage
Store IQSEC2 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of IQSEC2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for IQSEC2 blocking peptide
Blocking (BL)
Application Notes for IQSEC2 blocking peptide
IQSEC2 peptide is used for blocking the activity of IQSEC2 antibody.
NCBI/Uniprot data below describe general gene information for IQSEC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104595
[Other Products]
NCBI GenBank Nucleotide #
NM_001111125.2
[Other Products]
UniProt Primary Accession #
Q5JU85
[Other Products]
UniProt Secondary Accession #
O60275; Q5JUX1; B3KT97; C7SDG1[Other Products]
UniProt Related Accession #
Q5JU85[Other Products]
Molecular Weight
105,100 Da
NCBI Official Full Name
IQ motif and SEC7 domain-containing protein 2 isoform 1
NCBI Official Synonym Full Names
IQ motif and Sec7 domain 2
NCBI Official Symbol
IQSEC2 [Similar Products]
NCBI Official Synonym Symbols
MRX1; BRAG1
[Similar Products]
NCBI Protein Information
IQ motif and SEC7 domain-containing protein 2; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c
UniProt Protein Name
IQ motif and SEC7 domain-containing protein 2
Protein Family
IQ motif and SEC7 domain-containing protein
UniProt Gene Name
IQSEC2 [Similar Products]
UniProt Synonym Gene Names
KIAA0522 [Similar Products]
UniProt Entry Name
IQEC2_HUMAN
NCBI Summary for IQSEC2
This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IQSEC2
IQSEC2: Defects in IQSEC2 are the cause of mental retardation X- linked type 1 (MRX1). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. Belongs to the BRAG family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, ARF; GEFs
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component: trans-Golgi network; nucleus; cell junction
Molecular Function: ARF guanyl-nucleotide exchange factor activity
Biological Process: vesicle-mediated transport; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
Disease: Mental Retardation, X-linked 1
Research Articles on IQSEC2
1. Truncating mutations in IQSEC2 are responsible for syndromic severe intellectual disability in male patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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