Full Product Name
Anti-MFRP (membrane-type frizzled-related protein MFRP) Antibody
Product Gene Name
anti-MFRP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BY79
Species Reactivity
Human, Mouse
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MFRP (membrane-type frizzled-related protein MFRP)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-MFRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MFRP antibody
MFRP (membrane-type frizzled-related protein MFRP) may play a role in eye development. MFRP is a single-pass type II membrane protein. It is specifically expressed in brain and is strongly expressed in medulla oblongata and to a lower extent in hippocampus and corpus callosum. Defects in MFRP are the cause of nanophthalmos 2 (NNO2). NNO2 is a rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes.
Applications Tested/Suitable for anti-MFRP antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MFRP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_113621.1
[Other Products]
NCBI GenBank Nucleotide #
NM_031433.3
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UniProt Primary Accession #
Q9BY79
[Other Products]
UniProt Secondary Accession #
Q335M3; Q96DQ9; B0YJ36; B0YJ37; B4DHN8[Other Products]
UniProt Related Accession #
Q9BY79[Other Products]
Molecular Weight
48,919 Da
NCBI Official Full Name
membrane frizzled-related protein
NCBI Official Synonym Full Names
membrane frizzled-related protein
NCBI Official Symbol
MFRP [Similar Products]
NCBI Official Synonym Symbols
RD6; NNO2; MCOP5
[Similar Products]
NCBI Protein Information
membrane frizzled-related protein
UniProt Protein Name
Membrane frizzled-related protein
UniProt Synonym Protein Names
Membrane-type frizzled-related protein
Protein Family
Membrane frizzled-related protein
UniProt Gene Name
MFRP [Similar Products]
NCBI Summary for MFRP
This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). [provided by RefSeq, Jun 2013]
UniProt Comments for MFRP
MFRP: May play a role in eye development. Defects in MFRP are the cause of nanophthalmos 2 (NNO2). NNO2 is a rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes. Defects in MFRP are the cause of microphthalmia isolated type 5 (MCOP5). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. MCOP5 is characterized by posterior microphthalmia, retinitis pigmentosa, foveoschisis and optic disc drusen.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: integral to membrane
Disease: Microphthalmia, Isolated 5; Nanophthalmos 2
Product References and Citations for anti-MFRP antibody
Katoh, M., Biochem. Biophys. Res. Commun. 282 (1), 116-123 (2001) Mandal, M.N., et al, Invest. Ophthalmol. Vis. Sci. 46 (9), 3355-3362 (2005) Yang, L., et al, J. Dermatol. Sci. 42 (2), 111-119 (2006) Pauer, G.J., et al, Ophthalmic Genet. 26 (4), 157-161 (2005) Sundin, O.H., et al, Proc. Natl. Acad. Sci. U.S.A. 102 (27), 9553-9558 (2005)
Research Articles on MFRP
1. The current study expands our knowledge of the mutation spectrum of MFRP and its associated phenotypes. To our knowledge, this is the first report of MFRP mutations in a Chinese cohort.
Precautions
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Disclaimer
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