PER2, Polyclonal Antibody

FASPS; FASPS1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total PER2 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.9 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-PER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic Nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:100-1:300

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/50.

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/50.

45,175 Da

period circadian clock 2

period circadian protein homolog 2

Period circadian protein homolog 2

KIAA0347; hPER2  [Similar Products]

PER2_HUMAN

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

PER2: a transcription factor belonging to the basic helix-loop-helix (bHLH) family. A member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Expression oscillates with a 24 hr rhythm in the suprachiasmatic nucleus and the whole eyes. Oscillations are maintained under constant darkness and are responsive to changes of the light/dark cycles. There is a 4 hour time delay between per1 and per2 oscillations. The expression rhythms appear to originate from retina.

Protein type: Transcription factor; Nuclear receptor co-regulator; Nucleolus

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: signal transducer activity; protein binding; ubiquitin binding; histone deacetylase binding; transcription coactivator activity; kinase binding; nuclear hormone receptor binding

Biological Process: circadian rhythm; glycogen biosynthetic process; transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; fatty acid metabolic process; signal transduction; regulation of glutamate uptake during transmission of nerve impulse; gluconeogenesis; regulation of neurogenesis; regulation of vasoconstriction; white fat cell differentiation; lactate biosynthetic process; negative regulation of protein ubiquitination; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion

Disease: Advanced Sleep Phase Syndrome, Familial, 1

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