Dual Oxidase 2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against DUOX2. It has beenselected for its ability to recognize DUOX2 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-DUOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Recombinant protein.

DABstainingonIHC-P.Samples:RatTissue)

52,576 Da

dual oxidase 2

dual oxidase 2

Dual oxidase 2

Lnox2; Thox2  [Similar Products]

a thyroid NADPH oxidase flavoprotein [RGD, Feb 2006]

DUOX2: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6). A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.

Protein type: EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase

Chromosomal Location of Human Ortholog: 3q35

Cellular Component: apical plasma membrane; cell junction; integral component of membrane

Molecular Function: calcium ion binding; heme binding; NAD(P)H oxidase activity; peroxidase activity

Biological Process: adenohypophysis morphogenesis; bone mineralization; cuticle development; cytokine-mediated signaling pathway; fertilization; hormone biosynthetic process; hormone metabolic process; hydrogen peroxide biosynthetic process; hydrogen peroxide catabolic process; inner ear development; multicellular organism growth; response to cAMP; response to oxidative stress; response to virus; thyroid gland development; thyroid hormone generation; thyroid hormone metabolic process

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