Full Product Name
FOXI1 Antibody, Biotin conjugated
Product Synonym Names
Forkhead box protein I1; Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3; FOXI1; FKHL10; FREAC6
Product Gene Name
anti-FOXI1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q12951
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Forkhead box protein I1 protein (183-343AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FOXI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FOXI1 antibody
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
Applications Tested/Suitable for anti-FOXI1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FOXI1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036320.2
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NCBI GenBank Nucleotide #
NM_012188.4
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UniProt Primary Accession #
Q12951
[Other Products]
UniProt Secondary Accession #
Q14518; Q66SR7; Q8N6L8[Other Products]
UniProt Related Accession #
Q12951[Other Products]
Molecular Weight
30,814 Da
NCBI Official Full Name
forkhead box protein I1 isoform a
NCBI Official Synonym Full Names
forkhead box I1
NCBI Official Symbol
FOXI1 [Similar Products]
NCBI Official Synonym Symbols
HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6
[Similar Products]
NCBI Protein Information
forkhead box protein I1
UniProt Protein Name
Forkhead box protein I1
UniProt Synonym Protein Names
Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3
Protein Family
Forkhead box protein
UniProt Gene Name
FOXI1 [Similar Products]
UniProt Synonym Gene Names
FKHL10; FREAC6; FREAC-6; HFH-3; HNF-3/fork-head homolog 3 [Similar Products]
NCBI Summary for FOXI1
This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017]
UniProt Comments for FOXI1
FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter
Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome
Research Articles on FOXI1
1. We found no evidence for a significant association between mutations of KCNJ10 and FOXI1 with SLC26A4 in Pendred syndrome/enlarged vestibular aqueducts.
Precautions
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Disclaimer
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