Product Name
C1 esterase inhibitor (SERPING1), Polyclonal Antibody
Full Product Name
Goat anti Human C1 esterase inhibitor
Product Gene Name
anti-SERPING1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12.1
3D Structure
ModBase 3D Structure for P05155
Specificity
Precipitating polyclonal Goat antiSerum to Human C1 esterase inhibitor
Reactivity Note
The antiSerum does not cross react with any other component of Human plasma. Inter-species cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-SERPING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-SERPING1 antibody
Complement, Coagulation, Haematology
Applications Tested/Suitable for anti-SERPING1 antibody
Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
NCBI Accession #
AAM21515.1
[Other Products]
UniProt Primary Accession #
P05155
[Other Products]
UniProt Secondary Accession #
Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; Q9UCF9; A6NMU0; A8KAI9; B2R6L5[Other Products]
UniProt Related Accession #
P05155[Other Products]
Molecular Weight
55,154 Da[Similar Products]
NCBI Official Full Name
C1 esterase inhibitor
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol
SERPING1 [Similar Products]
NCBI Official Synonym Symbols
C1IN; C1NH; HAE1; HAE2; C1INH
[Similar Products]
NCBI Protein Information
plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Protein Family
Plasma protease C1 inhibitor
UniProt Gene Name
SERPING1 [Similar Products]
UniProt Synonym Gene Names
C1IN; C1NH; C1 Inh; C1Inh [Similar Products]
UniProt Entry Name
IC1_HUMAN
NCBI Summary for SERPING1
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPING1
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with ***** macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q12.1
Cellular Component: extracellular space; extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding
Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; complement activation, classical pathway; blood coagulation, intrinsic pathway; aging
Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
Research Articles on SERPING1
1. Our study identified four novel mutations in the Slovenian HAE population, highlighting the heterogeneity of mutations in the SERPING1 gene causing C1 inhibitor deficiency and Hereditary angioedema .
Precautions
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Disclaimer
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