Product Name
FOXC1, Blocking Peptide
Full Product Name
FOXC1 (C Term) Immunizing Peptide
Product Synonym Names
FOXC1; forkhead box C1; ARA; IGDA; IHG1; FKHL7; IRID1; FREAC3; iridogoniodysgenesis type 1; forkhead (Drosophila)-like 7; forkhead-related activator 3; Forkhead, drosophila, homolog-like 7; FREAC-3; RIEG3; forkhead/winged helix-like transcription factor 7; FOXC1 (C Term)
Product Gene Name
FOXC1 blocking peptide
[Similar Products]
FOXC1 peptide (MBS428540) is used for blocking the activity of FOXC1 antibody (MBS420865)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of FOXC1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FOXC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001444.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001453.2
[Other Products]
UniProt Secondary Accession #
Q86UP7; Q9BYM1; Q9NUE5; Q9UDD0; Q9UP06[Other Products]
UniProt Related Accession #
Q12948[Other Products]
Molecular Weight
56,789 Da
NCBI Official Full Name
forkhead box protein C1
NCBI Official Synonym Full Names
forkhead box C1
NCBI Official Symbol
FOXC1 [Similar Products]
NCBI Official Synonym Symbols
ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3
[Similar Products]
NCBI Protein Information
forkhead box protein C1
UniProt Protein Name
Forkhead box protein C1
UniProt Synonym Protein Names
Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3
Protein Family
Forkhead box protein
UniProt Gene Name
FOXC1 [Similar Products]
UniProt Synonym Gene Names
FKHL7; FREAC3; FREAC-3 [Similar Products]
UniProt Entry Name
FOXC1_HUMAN
NCBI Summary for FOXC1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXC1
FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus
Molecular Function: DNA bending activity; DNA binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: artery morphogenesis; blood vessel remodeling; brain development; camera-type eye development; cardiac muscle cell proliferation; cell migration; cell proliferation; collagen fibril organization; embryonic heart tube development; eye development; germ cell migration; glycosaminoglycan metabolic process; heart development; in utero embryonic development; lacrimal gland development; lymph vessel development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; neural crest cell development; Notch signaling pathway; odontogenesis of dentine-containing teeth; ossification; ovarian follicle development; paraxial mesoderm formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood vessel size; regulation of organ growth; regulation of transcription, DNA-dependent; skeletal development; somitogenesis; transcription from RNA polymerase II promoter; ureteric bud development; vascular endothelial growth factor receptor signaling pathway; ventricular cardiac muscle morphogenesis
Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
Research Articles on FOXC1
1. These findings suggest that miR-4792 functions as a tumor suppressor in NPC development and progression by targeting FOXC1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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