SP100, Monoclonal Antibody

Anti -SP100 (Nuclear Autoantigen Sp-100, Lysp100b, Nuclear Dot-associated Sp100 Protein, Speckled 100kD)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (231280871..231410317). Location: 2q37.1

Monoclonal

IgG2a, k

1G6

Mouse

Recognizes human SP100.

Purified
Purified.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-SP100 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SP100 forms a homodimer and may play a role in the control of gene expression. It localizes to nuclear bodies (NBs), also referred to as Kr-bodies, ND10, or PODs. Splice variants of SP100 heterodimerize. SP100 interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif.

Antibodies; Abs to Nuclear Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.

100,417 Da[Similar Products]

SP100 nuclear antigen

nuclear autoantigen Sp-100; lysp100b; speckled 100 kDa; OTTHUMP00000164262; OTTHUMP00000204340; OTTHUMP00000204342; nuclear antigen Sp100; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein

Nuclear autoantigen Sp-100

SP100_HUMAN

This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

SP100: May play a role in the control of gene expression. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; PML body; Mre11 complex; cytoplasm; nucleolus; nucleus

Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein homodimerization activity; DNA binding; transcription coactivator activity; chromatin binding; kinase binding; transcription corepressor activity; transcription factor binding

Biological Process: retinoic acid receptor signaling pathway; response to retinoic acid; negative regulation of protein export from nucleus; viral reproduction; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of cell motility; negative regulation of transcription from RNA polymerase II promoter; regulation of angiogenesis; negative regulation of DNA binding; chromatin remodeling; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of viral transcription; response to cytokine stimulus; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; telomere maintenance

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