URAT1, Polyclonal Antibody

OAT4L, OATL4, Renal specific transporter, RST, SLC22A12, URAT1, Urate anion exchanger 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Purification: Immunogen affinity purified
Purity: > or = 95% as determined by SDS-PAGE

Liquid

-20°C for 24 months (Avoid repeated freeze / thaw cycles.)

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-URAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Human urate anion exchanger (URAT1), also known as SLC22A12, is a urate transporter located in the proximal tubules of human kidney and responsible for urate reabsorption. Defects in gene encoding URAT1 cause hypouricemia renal type 1 (RHUC1). This antibody recognizes the native and glycosylated URAT1 between 65 and 70 kDa as well as the truncated 40kDa protein.

ELISA (EIA), Western Blot (WB)

WB : 1:200-1:2000

PC-13 cells were subjected to SDS PAGE followed by western blot with MBS7605518 (URAT1 antibody) at dilution of 1:600

solute carrier family 22 member 12

solute carrier family 22 member 12

Solute carrier family 22 member 12

OATL4; URAT1; RST  [Similar Products]

S22AC_HUMAN

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: inorganic anion exchanger activity; PDZ domain binding; sodium-independent organic anion transmembrane transporter activity; urate transmembrane transporter activity

Biological Process: cellular homeostasis; response to drug; sodium-independent organic anion transport; urate metabolic process; urate transport

Disease: Hypouricemia, Renal, 1

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