Product Name
Cyclic nucleotide-gated cation channel alpha-3 (CNGA3), Recombinant Protein
Full Product Name
Recombinant Human Cyclic nucleotide-gated cation channel alpha-3 (CNGA3), partial
Product Gene Name
CNGA3 recombinant protein
[Similar Products]
Product Synonym Gene Name
CNGA3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16281
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CNGA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CNGA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001073347.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001079878.1
[Other Products]
UniProt Primary Accession #
Q16281
[Other Products]
UniProt Secondary Accession #
Q4VAP7; Q53RD2; Q6ZNA7; Q9UP64; E9PF93[Other Products]
UniProt Related Accession #
Q16281[Other Products]
Molecular Weight
79,062 Da
NCBI Official Full Name
cyclic nucleotide-gated cation channel alpha-3 isoform 2
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 3
NCBI Official Symbol
CNGA3 [Similar Products]
NCBI Official Synonym Symbols
CNG3; ACHM2; CCNC1; CCNCa; CNCG3; CCNCalpha
[Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel alpha-3
UniProt Protein Name
Cyclic nucleotide-gated cation channel alpha-3
UniProt Synonym Protein Names
Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
Protein Family
Cyclic nucleotide-gated cation channel
UniProt Gene Name
CNGA3 [Similar Products]
UniProt Synonym Gene Names
CNCG3; CNG channel alpha-3; CNG-3; CNG3 [Similar Products]
NCBI Summary for CNGA3
This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for CNGA3
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Research Articles on CNGA3
1. A, p.Gly540Ser substitution in CNGA3 was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 ACHM patients; the majority of them carry missense rather than premature-termination mutations.">The c.1618G>A, p.Gly540Ser substitution in CNGA3 was identified as the causative mutation for a novel form of ACHM in Awassi sheep. Gene augmentation therapy restored vision in the affected sheep. This novel mutation provides a large-animal model that is valid for most human CNGA3 ACHM patients; the majority of them carry missense rather than premature-termination mutations.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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