Product Name
Cyclic nucleotide-gated cation channel alpha-3 (CNGA3), Recombinant Protein
Full Product Name
Recombinant Bovine Cyclic nucleotide-gated cation channel alpha-3 (CNGA3)
Product Gene Name
CNGA3 recombinant protein
[Similar Products]
Product Synonym Gene Name
CNCG3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-706aa; full length protein
Sequence
MAKISTQYSH PTRTHPSVRT MDRDLDCIEN GLSRTHLPCE ETSSELQEGI AMETRGLAES RQSSFTSQGP TRLSRLIISL RAWSARHLHQ EDQRPDSFLE RFRGAELQEV SSRESHVQFN VGSQEPPDRG RSAWPLARNN TNTCNNSEKD DKAKKEEKEK KEEKKENPKK EEKKKDSVVM DPSSNMYYHW LTVIAVPVFY NWCLLVCRAC FDELQSEHLM LWLVLDYSAD ILYGMDMLVR ARTGFLEQGL MVMDASRLWK HYTQTLHFKL DVLSLVPTDL AYFKLGMNYP ELRFNRLLKL ARLFEFFDRT ETRTNYPNMF RIGNLVLYIL IIIHWNACIY FAISKFIGFG TDSWVYPNVS NPEYGRLSRK YIYSLYWSTL TLTTIGETPP PVKDEEYLFV VIDFLVGVLI FATIVGNVGS MISNMNASRA EFQAKIDSIK QYMQFRKVTK DLETRVIRWF DYLWANKKTV DEKEVLKSLP DKLKAEIAIN VHLDTLRKVR IFQDCEAGLL VELVLKLRPA VFSPGDYICK KGDIGREMYI IKEGKLAVVA EDGITQFVVL GDGSYFGEIS ILNIKGSKSG NRRTANIRSI GYSDLFCLSK DDLMEALTEY PEAKKALEEK GRQILMKDNL IDEELAKAGA DPKDIEEKVE HLETSLDSLQ TRFARLLAEY NATQMKVKQR LSQLESQVKM GLPPDGDAPQ TEASQP
3D Structure
ModBase 3D Structure for Q29441
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CNGA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for CNGA3 recombinant protein
Transmembrane Protein
Application Notes for CNGA3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for CNGA3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776704.1
[Other Products]
NCBI GenBank Nucleotide #
NM_174279.2
[Other Products]
UniProt Primary Accession #
Q29441
[Other Products]
UniProt Related Accession #
Q29441[Other Products]
Molecular Weight
81,132 Da
NCBI Official Full Name
cyclic nucleotide-gated cation channel alpha-3
NCBI Official Symbol
CNGA3 [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel alpha-3
UniProt Protein Name
Cyclic nucleotide-gated cation channel alpha-3
UniProt Synonym Protein Names
Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
Protein Family
Cyclic nucleotide-gated cation channel
UniProt Gene Name
CNGA3 [Similar Products]
UniProt Synonym Gene Names
CNCG3; CNG channel alpha-3; CNG-3; CNG3 [Similar Products]
UniProt Entry Name
CNGA3_BOVIN
UniProt Comments for CNGA3
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (). Could be responsible for cGMP-induced calcium entry in cells other than sensory cells. Might be involved in chemotaxis of sperm.
Research Articles on CNGA3
1. the S4 structural motif of CNGA3 is important for cellular processing of cone photoreceptor cyclic GMP-gated ion channels
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
