Product Name
Angiogenic factor with G patch and FHA domains 1 (AGGF1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Angiogenic factor with G patch and FHA domains 1 polyclonal Antibody(AGGF1)
Product Synonym Names
Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein; AGGF1; GPATC7; GPATCH7; VG5Q
Product Gene Name
anti-AGGF1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N302
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen
Recombinant human Angiogenic factor with G patch and FHA domains 1 protein (1-70aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47569 / sc-47570 / sc-135246
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-AGGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AGGF1 antibody
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion.
Applications Tested/Suitable for anti-AGGF1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AGGF1 antibody
Recommended dilution: IHC:1:20-1:200
Immunohistochemistry (IHC) of anti-AGGF1 antibody
Immunohistochemistry of paraffin-embedded human placenta using MBS1495155 at dilution 1:100
Immunohistochemistry (IHC) of anti-AGGF1 antibody
Immunohistochemistry of paraffin-embedded human spleen using MBS1495155 at dilution 1:100
NCBI/Uniprot data below describe general gene information for AGGF1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060516.2
[Other Products]
NCBI GenBank Nucleotide #
NM_018046.4
[Other Products]
UniProt Primary Accession #
Q8N302
[Other Products]
UniProt Secondary Accession #
O00581; Q53YS3; Q9BU84; Q9NW66[Other Products]
UniProt Related Accession #
Q8N302[Other Products]
Molecular Weight
20,506 Da
NCBI Official Full Name
angiogenic factor with G patch and FHA domains 1
NCBI Official Synonym Full Names
angiogenic factor with G-patch and FHA domains 1
NCBI Official Symbol
AGGF1 [Similar Products]
NCBI Official Synonym Symbols
VG5Q; GPATC7; GPATCH7; HSU84971; HUS84971
[Similar Products]
NCBI Protein Information
angiogenic factor with G patch and FHA domains 1
UniProt Protein Name
Angiogenic factor with G patch and FHA domains 1
UniProt Synonym Protein Names
Angiogenic factor VG5Q; hVG5Q; G patch domain-containing protein 7; Vasculogenesis gene on 5q protein
Protein Family
Angiogenic factor with G patch and FHA domains
UniProt Gene Name
AGGF1 [Similar Products]
UniProt Synonym Gene Names
GPATC7; GPATCH7; VG5Q; hVG5Q [Similar Products]
UniProt Entry Name
AGGF1_HUMAN
NCBI Summary for AGGF1
This gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.[provided by RefSeq, Sep 2010]
UniProt Comments for AGGF1
AGGF1: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS). KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA processing; Cell adhesion
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: cytoplasm; extracellular region; perinuclear region of cytoplasm
Molecular Function: nucleic acid binding; protein binding
Biological Process: angiogenesis; cell adhesion; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; RNA processing; vasculogenesis
Disease: Klippel-trenaunay-weber Syndrome
Research Articles on AGGF1
1. AGGF1 reduces myocardial apoptosis and inflammation and enhances angiogenesis, leading to decreased infarct size after I/R injury.
Precautions
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Disclaimer
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