Product Name
Epsilon-sarcoglycan (Sgce), Recombinant Protein
Full Product Name
Epsilon-sarcoglycan
Product Gene Name
Sgce recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-437aa; full length protein
Sequence
MLLFWWWELG DPCAWTGKGR GTLKMSPATT GTFLLTVYTL FSKVHSDRNV YPSAGVLFVH VLEREYFKGE FPPYPKPGEV SNDPITFNTN LMGYPDRPGW LRYIQRTPYS DGVLYGSPTA ENVGKPTIIE ITAYNRRTFE TARHNLIINI MSAEEFPLPY QAEFFIKNMN VEEMLASEVL GDFLGAVKNV WQPERLNAIN ITSALDRGGR VPLPINDMKE GVYVMVGADV AFSSCLREVE NPQNQLRCSQ EMEPVITCDK KFRTHFHIDW CKISLVDKTK QVSTYQEVVR GEGILPDGGE YKPPSDSLKS RDYYTDFLVT LAVPSAVALV LFLILAYIMC CRREGVEKRD MQTPDIQLVH HSSIQKSTKE LRDMSKNREI AWPLSTLPVF HPVTGEVIPP THTDNYDSTN MPLMQAQQNL PHQTQIPQPQ TTGKWYP
3D Structure
ModBase 3D Structure for O70258
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Sgce recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Sgce recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Sgce recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Sgce. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123660.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130188.1
[Other Products]
UniProt Primary Accession #
O70258
[Other Products]
UniProt Secondary Accession #
Q921G2[Other Products]
UniProt Related Accession #
O70258[Other Products]
Molecular Weight
53,532 Da
NCBI Official Full Name
epsilon-sarcoglycan isoform 1
NCBI Official Synonym Full Names
sarcoglycan, epsilon
NCBI Official Symbol
Sgce [Similar Products]
NCBI Official Synonym Symbols
e-SG
[Similar Products]
NCBI Protein Information
epsilon-sarcoglycan
UniProt Protein Name
Epsilon-sarcoglycan
Protein Family
Epsilon-sarcoglycan
UniProt Gene Name
Sgce [Similar Products]
UniProt Synonym Gene Names
Epsilon-SG [Similar Products]
UniProt Entry Name
SGCE_MOUSE
UniProt Comments for Sgce
SGCE: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCE are a cause of dystonia type 11 (DYT11); also known as myoclonic dystonia or alcohol- responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the sarcoglycan alpha/epsilon family.
Protein type: Cell adhesion; Membrane protein, integral
Cellular Component: dystrophin-associated glycoprotein complex; Golgi apparatus; integral to plasma membrane; plasma membrane; sarcoglycan complex
Molecular Function: protein binding
Biological Process: muscle system process
Research Articles on Sgce
1. The results suggest that varepsilon-sarcoglycan in the cerebellar Purkinje cells contributes to the motor learning, while loss of varepsilon-sarcoglycan in other brain regions may contribute to nuclear envelope abnormality, myoclonus and motor coordination deficits.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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