Product Name
PSTPIP1, cDNA Clone
Full Product Name
PSTPIP1 cDNA Clone
Product Gene Name
PSTPIP1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgatgcccc agctgcagtt caaagatgcc ttttggtgca gggacttcac agcccacacg ggctacgagg tgctgctgca gcggcttctg gatggcagga agatgtgcaa agacatggag gagctactga ggcagagggc ccaggcggag gagcggtacg ggaaggagct ggtgcagatc gcacggaagg caggtggcca gacggagatc aactccctga gggcctcctt tgactccttg aagcagcaaa tggagaatgt gggcagctca cacatccagc tggccctgac cctgcgtgag gagctgcgga gtctcgagga gtttcgtgag aggcagaagg agcagaggaa gaagtatgag gccgtcatgg accgggtcca gaagagcaag ctgtcgctct acaagaaggc catggagtcc aagaagacat acgagcagaa gtgccgggac gcggacgacg cggagcaggc cttcgagcgc attagcgcca acggccacca gaagcaggtg gagaagagtc agaacaaagc caggcagtgc aaggactcgg ccaccgaggc agagcgggta tacaggcaga gcattgcgca gctggagaag gtccgggctg agtgggagca ggagcaccgg accacctgtg aggcctttca gctgcaagag tttgaccggc tgaccattct ccgcaacgcc ctgtgggtgc acagcaacca gctctccatg cagtgtgtca aggatgatga gctctacgag gaagtgcggc tgacgctgga aggctgcagc atagacgccg acatcgacag tttcatccag gccaagagca cgggcacaga gccccccgct ccggtgccct accagaacta ttacgatcgg gaggtcaccc cgctgaccag cagccctggc atacagccgt cctgcggcat gataaagagg ttctctggac tgctgcacgg aagtcccaag accacttcgt tggcagcttc tgctgcgtcc acagagaccc tgacccccac ccccgagcgg aatgagggtg tctacacagc catcgcagtg caggagatac agggaaaccc ggcctcacca gcccaggagt accgggcgct ctacgattat acagcgcaga acccagatga gctggacctg tccgcgggag acatcctgga ggtgatcctg gaaggggagg atggctggtg gactgtggag aggaacgggc agcgtggctt cgtccctggt tcctacctgg agaagctttg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PSTPIP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PSTPIP1. It may not necessarily be applicable to this product.
NCBI Accession #
BC008602
[Other Products]
UniProt Secondary Accession #
O43585; O95657; B5BU74; B5BUK4[Other Products]
UniProt Related Accession #
O43586[Other Products]
Molecular Weight
45,354 Da
NCBI Official Full Name
Homo sapiens proline-serine-threonine phosphatase interacting protein 1, mRNA
NCBI Official Synonym Full Names
proline-serine-threonine phosphatase interacting protein 1
NCBI Official Symbol
PSTPIP1 [Similar Products]
NCBI Official Synonym Symbols
H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S
[Similar Products]
NCBI Protein Information
proline-serine-threonine phosphatase-interacting protein 1
UniProt Protein Name
Proline-serine-threonine phosphatase-interacting protein 1
UniProt Synonym Protein Names
CD2-binding protein 1; H-PIP
Protein Family
Proline-serine-threonine phosphatase-interacting protein
UniProt Gene Name
PSTPIP1 [Similar Products]
UniProt Synonym Gene Names
CD2BP1; PEST phosphatase-interacting protein 1 [Similar Products]
UniProt Entry Name
PPIP1_HUMAN
NCBI Summary for PSTPIP1
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
UniProt Comments for PSTPIP1
PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: cytosol; membrane
Molecular Function: protein binding
Biological Process: signal transduction
Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Research Articles on PSTPIP1
1. genetic polymorphism is associated with hyperzincemia and hypercalprotectinemia
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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