Product Name
DIO1, cDNA Clone
Full Product Name
DIO1 cDNA Clone
Product Gene Name
DIO1 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGGGGCTGC CCCAGCCAGG GCTGTGGCTG AAGAGGCTCT GGGTGCTCTT GGAGGTGGCT GTGCATGTGG TCGTGGGTAA AGTGCTTCTG ATATTGTTTC CAGACAGAGT CAAGCGGAAC ATCCTGGCCA TGGGCGAGAA GACGGGTATG ACCAGGAACC CCCATTTCAG CCACGACAAC TGGATACCAA CCTTTTTCAG CACCCAGTAT TTCTGGTTCG TCTTGAAGGT CCGTTGGCAG CGACTAGAGG ACACGACTGA GCTAGGGGGT CTGGCCCCAA ACTGCCCGGT GGTCCGCCTC TCAGGACAGA GGTGCAACAT TTGGGAGTTT ATGCAAGGTA ATAGGCCACT GGTGCTGAAT TTTGGAAGTT GTACCTGACC TTCATTTATG TTCAAATTTG ACCAGTTCAA GAGGCTTATT GAAGACTTTA GTTCCATAGC AGATTTTCTT GTCATTTACA TTGAAGAAGC ACATGCATCA GATGGCTGGG CTTTTAAGAA CAACATGGAC ATCAGAAATC ACCAGAACCT TCAGGATCGC CTGCAGGCAG CCCATCTACT GCTGGCCAGG AGCCCCCAGT GCCCTGTGGT GGTGGACACC ATGCAGAACC AGAGCAGCCA GCTCTACGCA GCACTGCCTG AGAGGCTCTA CATAATCCAG GAGGGCAGGA TCCTCTACAA GGGTAAATCT GGCCCTTGGA ACTACAACCC AGAGGAAGTT CGTGCTGTTC TGGAAAAGCT CCACAGTTAA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DIO1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DIO1. It may not necessarily be applicable to this product.
NCBI Accession #
BC107170
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UniProt Secondary Accession #
Q1RN02; Q3KNP8; Q6Q4C1; Q6Q4C2; Q6Q4C3; Q6Q4C4; Q6Q4C5; Q6Q4C6; Q6Q4C7; Q6Q4C9; Q8WWC6[Other Products]
UniProt Related Accession #
P49895[Other Products]
Molecular Weight
9,774 Da
NCBI Official Full Name
Homo sapiens deiodinase, iodothyronine, type I, mRNA
NCBI Official Synonym Full Names
deiodinase, iodothyronine type I
NCBI Official Symbol
DIO1 [Similar Products]
NCBI Official Synonym Symbols
5DI; TXDI1
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NCBI Protein Information
type I iodothyronine deiodinase
UniProt Protein Name
Type I iodothyronine deiodinase
UniProt Synonym Protein Names
5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase
Protein Family
Type I iodothyronine deiodinase
UniProt Gene Name
DIO1 [Similar Products]
UniProt Synonym Gene Names
ITDI1; TXDI1 [Similar Products]
UniProt Entry Name
IOD1_HUMAN
NCBI Summary for DIO1
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
UniProt Comments for DIO1
DIO1: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. Belongs to the iodothyronine deiodinase family. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.97.1.10; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: plasma membrane
Molecular Function: selenium binding; thyroxine 5'-deiodinase activity
Biological Process: thyroid hormone generation
Research Articles on DIO1
1. All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 function in HepG2 cells.
Precautions
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Disclaimer
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